ANTIMICROBIAL THERAPY WITH THE COMBINATIO N TICARCILLIN-CLAVULANIC ACID AMIKACIN IN POSTOPERATIVE URINARY-TRACT INFECTIONS AFTER MAJOR UROLOGIC SURGERY - ABOUT 59 CASES

Ticarcillin-clavulanic acid (Claventin (R)) and amikacin were administ ered in an open study to prevent and treat nosocomial urinary tract in fections, to 59 patients after major urological surgery. Postoperative course was event-free in 44 cases. 10 patients presented asymptomatic urinary tract infections due to gram negative bacilli, that did not r equire any change in antimicrobial therapy. 5 patients experienced sym ptomatic nosocomial infections, whose one was associated with a methic illin-Resistant Staphylococcus aureus septicemia that was treated by v ancomycin. The urinary tract infections were polymicrobial in only 3 c ases. The tolerance was quite satisfactory, and the protocol was effec tive in about 92% of cases. The combination of ticarcillin-clavulanic acid-amikacin is valuable and can be used as first step therapy to pre serve the ecology of the patients.