Ph. Wang et al., USE OF A LONG-ACTING GONADOTROPIN-RELEASING-HORMONE AGONIST FOR TREATMENT OF STEROID CELL TUMORS OF THE OVARY, Fertility and sterility, 69(2), 1998, pp. 353-355
Objective: To report a complete serologic response in a 50-year-old wo
man who received long-acting gonadotropin-releasing hormone agonist (G
nRH-A) therapy for steroid cell tumor of the ovary, not otherwise spec
ified. Design: Case report. Setting: University hospital-based reprodu
ctive biology unit. Patient(s): A 50-year-old female patient exhibited
persistent elevation of T(>2.0 ng/mL) after surgery for steroid cell
tumor of the ovary, not otherwise specified, stage IIA for 3 months. T
his elevation suggested the presence of some residual active tumor. In
tervention(s): All tumor evaluations, including those for tumor marker
s, a thorough physical examination, imaging studies, and evaluations o
f nuclear medicine studies were negative except for elevated serum T l
evels. The patient was treated with GnRH-a between the fourth month an
d sixth month postoperatively.Main Outcome Measure(s): Serum levels of
T and tumor survey. Result(s): The serum T levels returned to normal
limits after administration of the first does of GnRH-a. Follow-up of
tumor survey was negative. The patient was alive and free of disease 2
6 months after treatment wit GnRH-a. Conclusion(s): GnRH-a may be an a
lternative choice as adjuvant therapy for managing a persistent or rec
urrent hormone-producing steroid cell tumor of the ovary. (C) 1998 by
American Society for Reproductive Medicine.