RISE OF CYTOSOLIC CA2-BOUND GUANYLYL CYCLASE ACTIVITY IN RAT ENTEROCYTES BY HEAT-STABLE ENTEROTOXIN OF VIBRIO-CHOLERAE NON-01( AND ACTIVATION OF MEMBRANE)

Authors
CHAUDHURI AG BHATTACHARYA J NAIR GB TAKEDA T CHAKRABARTI MK
Citation
Ag. Chaudhuri et al., RISE OF CYTOSOLIC CA2-BOUND GUANYLYL CYCLASE ACTIVITY IN RAT ENTEROCYTES BY HEAT-STABLE ENTEROTOXIN OF VIBRIO-CHOLERAE NON-01( AND ACTIVATION OF MEMBRANE), FEMS microbiology letters, 160(1), 1998, pp. 125-129
Citations number
20
Categorie Soggetti
Microbiology
Journal title
FEMS microbiology letters → ACNP
ISSN journal
03781097
Volume
160
Issue
1
Year of publication
1998
Pages
125 - 129
Database
ISI
SICI code
0378-1097(1998)160:1<125:ROCCGC>2.0.ZU;2-M
Abstract
The cytosolic calcium level ([Ca2+](i)) and the membrane bound guanyly l cyclase activity in the isolated rat intestinal epithelial cells wer e investigated. Heat-stable enterotoxin of Vibrio cholerae non-01 (NAG -ST) was found to increase both the [Ca2+]i and the enzyme activity. T hese changes occur similarly until 5 min of incubation with NAG-ST, in dicating that these changes might be involved in NAG-ST induced signal transduction in rat enterocytes. (C) 1998 Published by Elsevier Scien ce B.V.