INTERRELATIONSHIP BETWEEN THE LEVEL OF CH OLESTEROL CONTAINING CIRCULATING IMMUNE-COMPLEXES AND SENSITIVITY OF LIPOPROTEINS TO LIPID-PEROXIDATION IN PATIENTS WITH ISCHEMIC-HEART-DISEASE

Interralationship between the level of cholesterol containing circulat ing immune complexes and intensity of chemiluminescence of lipids was studied in blood serum from 53 patients with and in 10 subjects withou t ischemic heart disease. Compared to subjects without ischemic heart disease the patients had significant elevation of concentration of cho lesterol containing circulating immune complexes and increased intensi ty of serum chemiluminescence induced by iron ions in the presence of peroxide, In patients with ischemic heart disease concentration of cho lesterol containing circulating immune complexes correlated positively with the magnitude of serum luminescence and negatively with the leve l of high density lipoproteins, History of myocardial infarction chang ed the direction of correlations between capacity of lipoproteins for oxidation and content of cholesterol containing circulating immune com plexes.