A PDGF-REGULATED IMMEDIATE-EARLY GENE RESPONSE INITIATES NEURONAL DIFFERENTIATION IN VENTRICULAR ZONE PROGENITOR CELLS

Authors
WILLIAMS BP PARK JK ALBERTA JA MUHLEBACH SG HWANG GY ROBERTS TM STILES CD
Citation
Bp. Williams et al., A PDGF-REGULATED IMMEDIATE-EARLY GENE RESPONSE INITIATES NEURONAL DIFFERENTIATION IN VENTRICULAR ZONE PROGENITOR CELLS, Neuron, 18(4), 1997, pp. 553-562
Citations number
62
Categorie Soggetti
Neurosciences
Journal title
Neuron → ACNP
ISSN journal
08966273
Volume
18
Issue
4
Year of publication
1997
Pages
553 - 562
Database
ISI
SICI code
0896-6273(1997)18:4<553:APIGRI>2.0.ZU;2-C
Abstract
When exposed to platelet-derived growth factor (PDGF), uncommitted neu roepithelial cells from the developing cortex of embryonic day 14 (E14 ) rats develop into neurons. Outward signs of the neuronal phenotype a re not observed for 4 days following exposure to PDGF. However, only a brief (23 hr) period of PDGF receptor activation is required to initi ate neuronal development. During the window of receptor activation, RN A synthesis is essential, but protein synthesis is not. These observat ions indicate that specification of neuronal fate is mediated by an im mediate early gene response.