MOUSE MUSCLE REGENERATION - AN IN-VIVO 2D H-1 MAGNETIC-RESONANCE SPECTROSCOPY (MRS) STUDY

Muscle degeneration and regeneration were studied by 2D H-1 magnetic r esonance spectroscopy (MRS) and histological examination, in an experi mental model of muscle injury using a myotoxic snake venom, notexin, T he injured muscles produced a very specific MRS signal, corresponding to a tri-unsaturated fatty acid (linolenic acid-like) signal, from day 2 to day 9 after injury, The combination of MRS with histology showed that this signal was associated with a mechanism occurring during myo blast fusion to form myotubes, 2D H-1 MRS is thus a useful non-invasiv e tool for detecting muscle regeneration in vivo. (C) 1998 Federation of European Biochemical Societies.