4 NEW IMMUNOSUPPRESSIVE COMPONENTS, KOBIIN AND KOBIFURANONE-A, KOBIFURANONE-B, AND KOBIFURANONE-C, FROM AN ASCOMYCETE, GELASINOSPORA-KOBI

Authors
FUJIMOTO H SATOH Y YAMAZAKI M
Citation
H. Fujimoto et al., 4 NEW IMMUNOSUPPRESSIVE COMPONENTS, KOBIIN AND KOBIFURANONE-A, KOBIFURANONE-B, AND KOBIFURANONE-C, FROM AN ASCOMYCETE, GELASINOSPORA-KOBI, Chemical and Pharmaceutical Bulletin, 46(2), 1998, pp. 211-216
Citations number
14
Categorie Soggetti
Chemistry Medicinal",Chemistry,"Pharmacology & Pharmacy
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
46
Issue
2
Year of publication
1998
Pages
211 - 216
Database
ISI
SICI code
0009-2363(1998)46:2<211:4NICKA>2.0.ZU;2-3
Abstract
A new sesterterpenetriol named kobiin and three new 2-furanones named kobifuranones A, B, and C were isolated from an Ascomycete, Gelasinosp ora kobi. Kobiin, the main immunosuppressive principle of this fungus, possesses a bicyclic skeleton of five-and fifteen-membered rings. Kob ifuranones A, B, and C were supposed to be metabolites formed from a c ommon intermediate biosynthesized through the acetate-malonate pathway . The immunosuppressive activity of kobiin and kobifuranones A, B, and C was evaluated in a system of mouse spleen lymphocytes stimulated to proliferate with concanavalin A and lipopolysaccharide.