NEW STEROIDAL CONSTITUENTS OF THE UNDERGROUND PARTS OF RUSCUS-ACULEATUS AND THEIR CYTOSTATIC ACTIVITY ON HL-60 CELLS

Authors
MIMAKI Y KURODA M KAMEYAMA A YOKOSUKA A SASHIDA Y
Citation
Y. Mimaki et al., NEW STEROIDAL CONSTITUENTS OF THE UNDERGROUND PARTS OF RUSCUS-ACULEATUS AND THEIR CYTOSTATIC ACTIVITY ON HL-60 CELLS, Chemical and Pharmaceutical Bulletin, 46(2), 1998, pp. 298-303
Citations number
15
Categorie Soggetti
Chemistry Medicinal",Chemistry,"Pharmacology & Pharmacy
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
46
Issue
2
Year of publication
1998
Pages
298 - 303
Database
ISI
SICI code
0009-2363(1998)46:2<298:NSCOTU>2.0.ZU;2-O
Abstract
Phytochemical examination of the underground parts of Riscus aculeatus has led to the isolation of a total of twelve steroidal saponins, inc luding seven new ones, The structures of the new saponins were determi ned by spectroscopic analysis and chemical evidence. The furostanol sa ponin, having a diglycoside moiety modified with a (2S,3S)-2-hydroxy-3 -methylpentanoic acid group and an acetic acid group, and its correspo nding spirostanol saponin exhibited cytostatic activity on leukemia HL -60 cells.