Y. Mimaki et al., NEW STEROIDAL CONSTITUENTS OF THE UNDERGROUND PARTS OF RUSCUS-ACULEATUS AND THEIR CYTOSTATIC ACTIVITY ON HL-60 CELLS, Chemical and Pharmaceutical Bulletin, 46(2), 1998, pp. 298-303
Phytochemical examination of the underground parts of Riscus aculeatus
has led to the isolation of a total of twelve steroidal saponins, inc
luding seven new ones, The structures of the new saponins were determi
ned by spectroscopic analysis and chemical evidence. The furostanol sa
ponin, having a diglycoside moiety modified with a (2S,3S)-2-hydroxy-3
-methylpentanoic acid group and an acetic acid group, and its correspo
nding spirostanol saponin exhibited cytostatic activity on leukemia HL
-60 cells.