A. Gehrt et al., NITIDON, A NEW BIOACTIVE METABOLITE FROM THE BASIDIOMYCETE JUNGHUHNIA-NITIDA (PERS., FR.) RYV, Zeitschrift fur Naturforschung. C, A journal of biosciences, 53(1-2), 1998, pp. 89-92
Nitidon, a highly oxidised pyranone derivative produced by the basidio
mycete Junghuhnia nitida, has been isolated and its biological activit
ies evaluated. The structure was determined by spectroscopic methods.
Nitidon exhibits antibiotic and cytotoxic activities and induces morph
ological and physiological differentiation of tumor cells at nanomolar
concentrations.