HEMOLYTIC-ACTIVITY OF AMINOETHYL-DODECANOATES

The effect of new lysosomotropic compounds on red blood cell hemolysis and erythrocyte membrane fluidity has been investigated. In earlier s tudies it was shown that the compounds inhibit the growth of yeast and plasma membrane H+-ATPase activity. The study was performed with eigh t aminoethyl esters of lauric acid variously substituted at nitrogen a tom. Esters of dodecanoic acid were chosen for study because at that c hain length dimethylaminoethyl esters showed maximum activity. The hem olytic activity of the substances studied exhibits diversified activit y in their interaction with the erythrocyte membrane: they differ in h emolytic activity and affect membrane fluidity differently. Erythrocyt e membrane fluidity changes under the effect of those compounds which possess highest hemolytic activity. The hemolytic activity of the amin oesters investigated was found to follow a sequence that depended on b asicity (i.e. ability of the protonated form formation) of the compoun d and its polar head group size. The most active are the compounds tha t possess not more than four carbon atoms substituted at nitrogen and highest pK(a), value.