BONE HEALING FOLLOWING THE USE OF HYDROXYAPATITE OR IONOMERIC BONE SUBSTITUTES ALONE OR COMBINED WITH A GUIDED BONE REGENERATION TECHNIQUE - AN ANIMAL STUDY
La. Salata et al., BONE HEALING FOLLOWING THE USE OF HYDROXYAPATITE OR IONOMERIC BONE SUBSTITUTES ALONE OR COMBINED WITH A GUIDED BONE REGENERATION TECHNIQUE - AN ANIMAL STUDY, The International journal of oral and maxillofacial implants, 13(1), 1998, pp. 44-51
The healing of standardized bone defects grafted with either particula
te ionomeric or hydroxyapatite bone substitutes was compared in the ma
ndibular ramus of 30 Sprague-Dawley rats. The possible additional resp
onse achieved when combining these materials with a guided bone regene
ration (GBR) technique was also evaluated. Three groups of 10 animals
received either no implant material or ionomeric or hydroxyapatite bon
e substitute in defects in the right ramus. The left mandibular defect
s received the same treatment, except that the operation site was cove
red by a membrane (GBR technique). Half of the animals were sacrificed
at 4 and 10 weeks following surgery, and the inflammatory response at
the implant site and the amount of new bone formed in the defects wer
e determined histomorphometrically. Defects implanted with ionomeric b
one substitute exhibited more bone formation (4 weeks = 3.19 +/- 0.38
mm(2), 10 weeks = 5.35 +/- 0.26 mm(2)) than both defects that received
no treatment (4 weeks = 0.88 +/- 0.35 mm(2), 10 weeks = 2.1 +/- 0.49
mm(2)), membrane alone (4 weeks = 1.21 +/- 0.05 mm(2)) or hydroxyapati
te bone substitute (4 weeks = 1.41 +/- 0.46 mm(2), 10 weeks = 3.34 +/-
0.41 mm(2)) at 4 weeks (P less than or equal to .01) and at 10 weeks
(P less than or equal to .05). The use of a GBR technique did not incr
ease the amount of bone formed, compared to the use of bone substitute
s alone. Hydroxyapatite and ionomeric bone substitutes used alone were
more effective in inducing repair of the defects than was GBR membran
e alone. The use of hydroxyapatite was associated with a greater infla
mmatory reaction (P less than or equal to .01) than was ionomer in thi
s model.