THE EFFECTIVENESS OF INACTIVATED, PURIFIED AND CONCENTRATED EXPERIMENTAL RABIES VACCINE FOR VETERINARY USE - ANTIGENIC ACTIVITY - EXPERIMENTS ON DOMESTIC DOGS

The antigenic activity of experimental inactivated, concentrated, puri fied adjuvant rabies vaccine prepared by the authors was investigated in experiments on domestic dogs and compared with antigenic activity o f commercial rabies preparations at intramuscular application. The eff ectiveness of experimental vaccine was tested in domestic dogs also by non-traditional intradermal method of application at varying doses (0 .1 and 0.2 cm(3)). The results of determination of tables antibodies b y means of VNT and ELISA method at intramuscular administration of vac cines revealed that the antigenic activity of the experimental vaccine is comparable with that of commercial preparations. The effectiveness of the experimental vaccine at intradermal administration at a dose o f 0.2 cm(3) was even higher. The level of rabies antibodies was suffic ient after as many as 15 months following the intradermal administrati on of vaccine: in none of the experimental animals any values were det ected. The dose of 0.1 cm(3), administered intradermally, cannot ensur e adequate antirabies protection for the period of 15 months.