THE EFFECTS OF N-ACETYL CYSTEINE TREATMENT AND NITRIC-OXIDE SYNTHASE INHIBITION ON OXIDATIVE STRESS-INDUCED BY ESCHERICHIA-COLI ENDOTOXIN

In the present study, we have examined the effects of N-acetyl cystein e (NAG) on hepatic lipid peroxidation and glutathione levels in lipopo lysaccharide (LPS) and N-nitro-L-arginine (L-NAME) treated rats. LPS t reatment to rats resulted in increased lipid peroxide levels and decre ased glutathione (GSH) content in the liver homogenate and mitochondri a. NAC plus L-NAME administration attenuated all the abnormalities cau sed by LPS. In conclusion, it has been suggested that NAC may have som e beneficial effects in LPS + L-NAME treated rats.