DURATION OF ANTIMICROBIAL PROPHYLAXIS IN VASCULAR-SURGERY

BACKGROUND: This randomized clinical trial compares the incidence of w ound infection after vascular surgery in patients who received prophyl axis using the same antibiotic as either a single-dose or a multiple-d ose regimen (until the lines/drain tubes were removed, but not for mor e than 5 days). METHODS: Each of the 302 patients who entered the stud y received ticarcillin 3.0 g/clavulanate 0.1 g (Timentin) intravenousl y immediately after the induction of anesthesia. Patients randomized t o the multiple-dose group received an average of 14.3 doses (range 9 t o 20). RESULTS: The incidence of wound infections was 18% (28 of 153) for patients in the single-dose group and 10% (15 of 149) for patients in the multiple-dose group (P = 0.04; relative risk estimate = 2.00, 95% confidence Interval = -1.02 to 3.92). CONCLUSIONS: A multiple-dose antibiotic regimen, rather than single-dose therapy, provides optimal prophylaxis against wound infection for patients undergoing vascular surgery. (C) 1998 by Excerpta Medica, Inc.