HYDROLYTIC METALLOENZYME ACTIVITY OF ZINC (II) COMPLEX OF MACROCYCLICPOLYAMINES

Authors
CHEN WD ZHU SR LIN HK KOU FP LIN MR CHEN RT
Citation
Wd. Chen et al., HYDROLYTIC METALLOENZYME ACTIVITY OF ZINC (II) COMPLEX OF MACROCYCLICPOLYAMINES, Huaxue xuebao, 55(11), 1997, pp. 1097-1102
Citations number
11
Categorie Soggetti
Chemistry
Journal title
Huaxue xuebao → ACNP
ISSN journal
05677351
Volume
55
Issue
11
Year of publication
1997
Pages
1097 - 1102
Database
ISI
SICI code
0567-7351(1997)55:11<1097:HMAOZ(>2.0.ZU;2-Z
Abstract
The hydrolytic kinetics of p-nitrophenol acetate (NA) catalysized by z inc (II) complex of -dibromo)-benzyl-1,4,8,11-tetraazacyclotetradecane has been studied. It was shown that the catalytic hydrolytic rate was of first-order to both zinc (II) complex and NA concentrations. The s econd-order rate constant k(cat) = 0.12mol(-1).L.s(-1) (298K, I = 0. 1 0, 0.02mol.L-1 tris buffer). This is one of the most efficient hydroly tic metalloenzyme model compounds reported up to now. The present resu lts show that coordinated phenolate can serve as a new nucleophile tha t effectively catalyzes the hydrolysis of NA.