Between December 1987 and December 1995, 62 patients underwent orthoto
pic cardiac transplantation at Green Lane Hospital. Their cardiac dysf
unction resulted from dilated cardiomyopathy (32), coronary artery dis
ease (21), rheumatic heart disease (7), congenitally corrected transpo
sition of the great arteries (1) and hypertrophic cardiomyopathy (1).
Before transplantation all patients were in New York Heart Association
(NYHA) functional class III or IV. Eight patients (13%) died in the p
erioperative period and a further seven (11%) died 1 to 4 years after
transplantation. Actuarial 1 and 3 year survival was 87% and 80% respe
ctively. Forty-five of forty-seven surviving patients were in NYHA fun
ctional class I at the time ol analysis. The results confirm that card
iac transplantation has a limited but valuable role in the treatment o
f end stage myocardial dysfunction.