GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR-ASSOCIATED HISTIOCYTOSIS AND CAPILLARY-LEAK SYNDROME FOLLOWING AUTOLOGOUS BONE-MARROW TRANSPLANTATION - 2 CASE-REPORTS AND A REVIEW OF THE LITERATURE

Bone marrow (BM) histiocystosis in association with the administration of granulocyte-macrophage colony-stimulating factor (GM-CSF) is a rar e phenomenon with few published cases, We report two cases of BM histi ocystosis in patients with Hodgkin's disease treated with GM-CSF after autologous bone marrow transplantation, Both patients also developed clinical features of capillary leak syndrome, another rare complicatio n of GM-CSF administration, GM-CSF-induced histiocystosis should non b e considered in the differential diagnosis of delayed engraftment post -autotransplant.