TRICHOMONAS FETUS MENINGOENCEPHALITIS AFTER ALLOGENEIC PERIPHERAL-BLOOD STEM-CELL TRANSPLANTATION

Citation
S. Okamoto et al., TRICHOMONAS FETUS MENINGOENCEPHALITIS AFTER ALLOGENEIC PERIPHERAL-BLOOD STEM-CELL TRANSPLANTATION, Bone marrow transplantation, 21(1), 1998, pp. 89-91
Citations number
13
Categorie Soggetti
Hematology,Oncology,Immunology,Transplantation
Journal title
ISSN journal
02683369
Volume
21
Issue
1
Year of publication
1998
Pages
89 - 91
Database
ISI
SICI code
0268-3369(1998)21:1<89:TFMAAP>2.0.ZU;2-O
Abstract
A 34-year-old man with refractory acute myelogenous leukemia underwent allogeneic peripheral blood stem cell transplantation (PBSCT) from hi s HLA-matched sibling, Engraftment was prompt and no acute GVHD develo ped, However, high fever persisted even after engraftment, and the pat ient developed headache, diplopia, vertigo and nuchal rigidity on day 20 posttransplant, Cerebrospinal fluid (CSF) showed pleocytosis with n o detectable microorganisms, Despite therapy with broad-spectrum antib iotics, antifungal agents and antituberculous drugs, he developed rapi d mental deterioration with seizures and died on day 40, Just prior to his death, trichomonads were isolated from both CSF and urine, Scanni ng electron microscopic examination identified the trichomonad as Tric homonas foetus. At autopsy, trichomonads were detected histopathologic ally in an area involving meningoencephalitis. To our knowledge, this is the first case of T. foetus meningoencephalitis in a recipient of a llogeneic PBSCT and, more importantly, the first human case of T. foet us infection.