HIGH-INCIDENCE OF EARLY ANAPHYLACTOID REACTION TO SAIMR POLYVALENT SNAKE ANTIVENOM

During a prospective study of 147 patients with snakebite presenting t o a rural South African hospital, 13 of 17 patients (76%) treated with South African Institute for Medical Research (SAIMR) polyvalent antiv enom experienced potentially severe early (anaphylactoid) reactions. T he most common reaction was generalized urticaria (12; 71%), but 3 cas es of angio-oedema (18%), 2 of bronchospasm (12%), and 2 of hypotensio n (12%) were also observed. Reactions were controlled with adrenaline, antihistamines, and resuscitation. All patients fully recovered from envenoming although the full dose of antivenom was nor given to most. Indications for the use of this antivenom should be reconsidered and p atients should be given antivenom in a high care setting if possible. Use of antivenom by lay people outside hospital should be discouraged and antivenom manufacturing processes could usefully be reviewed.