TITRIMETRIC METHOD FOLLOWED BY SPECTROPHOTOMETRIC DETERMINATION OF SOME SELECTED CEPHALOSPORINS

A new, simple, rapid and sensitive method was established for the dete rmination of cefazolin sodium, cefaclor and cefadroxil in pharmaceutic al preparations. The aliquots of each sample were reacted with a stand ard potassium iodate in a moderate acidic medium after hydrolysis of b eta-lactamring with sodium hydroxide at 80 degrees C for 10 min. The a ppropriate stoichiometries were 1 mol cephalosporin to 2 mols iodate f or cefazolin sodium and cefadroxil; 1 mol to 3 mols iodate for cefaclo r. The cephalosporins were determined in the concentration range of 1- 5 mg ml(-1). The method's a within-day and day-to-day reproducibility was excellent.