LIPASE-CATALYZED RESOLUTION OF 2-DIALKYLAMINOMETHYLCYCLOHEXANOLS

The lipase PS-and Novozym 435-catalysed resolutions of 2-dialkylaminom ethylcyclohexanols (A-F) with various vinyl esters were studied in dif ferent organic media. High enantioselectivity (E>200) was observed whe n vinyl acetate was used as an acylating agent and diethyl ether as a solvent. The (1R,2R) enantiomers react preferentially in the case of t he cis isomers, whereas the (1R,2S) enantiomers do so in the case of t he trans counterparts, Reaction rates were markedly affected by the so lvent and by the quantity of the enzyme. (C) 1998 Elsevier Science Ltd . All rights reserved.