OLIGOFRUCTOSE MODULATES LIPID-METABOLISM ALTERATIONS INDUCED BY A FAT-RICH DIET IN RATS

The aim of this study was to test the hypothesis that non-digestible f ructans, namely oligofructose (OFS), are able to decrease post-prandia l lipaemia in rats fed a high-fat diet composed of 10% lard, 4% corn o il and 0.15% cholesterol. Male Wistar rats were divided into three gro ups: group 1 was fed a standard low-fat diet (AO4), group 2 received t he high-fat diet (HF) and group 3 received 10% (w/w) OFS in the HF die t (HF-OFS) for 3 weeks, The OFS supplementation reduced post-prandial triglyceridaemia by more than 50%, compared to both AO4 and HF groups. It also protected rats against the increase in free cholesterol serum level induced by the HF diet, The OFS did not prevent the HF-induced hepatic accumulation of triglycerides, phospholipids and cholesterol; however, histochemical analysis showed smaller lipid droplets in the l iver of HF-OFS rats as compared to HF rats, Our results suggest that, when given in HF diet, OFS decreases serum triglycerides through an ex tra-hepatic event, namely by enhancing triglyceride-rich lipoprotein c atabolism. (C) 1998 John Wiley & Sons, Ltd.