Conventional mechanical ventilation continues to be the standard mode
of support for neonates with respiratory failure. Controversies regard
ing the selection of optimal ventilatory strategies still abound. A de
ep understanding of physiologic concepts as well as a critical apprais
al of the literature is needed to optimize the ventilatory management
of the newborn. Principles of gas exchange, pulmonary mechanics and co
ntrol of breathing are reviewed in the context of their relevance duri
ng mechanical ventilation. The application of these concepts to the ve
ntilatory strategies for the management of infants with respiratory di
stress is presented, and current controversies are emphasized.