The use of sedation, muscle relaxation, or analgesia in the management
of ventilated neonates has been controversial. Many neonatologists fa
ce a difficult decision on whether or not to use a muscle relaxant on
a ventilated infant. This article reviews neonatal physiology and phar
macology, drug administration, absorption, distribution, and certain s
elected sedatives and analgesics. The muscle relaxants, financial issu
es, and family issues are also discussed.