PROLACTIN SECRETION IN MOLAR AND NORMAL-PREGNANCY

Objective: To describe the relation between PRL and hCG, T-3, T-4, fT( 4), TSH, E-2 and P-4 levels in normal pregnancies and those complicate d with GTD. Method: Twenty women, 10 with normal pregnancy and 10 with molar pregnancy were studied. The differences between them and the re lation between prolactin (PRL) and human chorionic gonadotropin (hCG), estradiol and thyroid hormones, thyroid stimulating hormone (TSH) and progesterone, was determined by Mann-Whitney U-test and Pearson's cor relation coefficient, respectively. Results: HCG, estradiol and thyroi d hormones were higher in molar pregnancy, but PRL and progesterone we re similar and TSH was lower in molar pregnancy. A negative correlatio n was found between PRL level and all the hormones in normal pregnancy , with the exception of TSH, and in molar pregnancy there was a positi ve correlation of PRL with all hormones. Conclusion: HCG, E-2, T-3, T- 4, fT(4) levels were higher in the group with molar pregnancy. Differe nces in correlation analysis suggest different endocrine regulation me chanisms in molar and normal pregnancies. (C) 1998 International Feder ation of Gynecology and Obstetrics.