NORMAL AND GESTATIONAL DIABETIC PREGNANCIES - LIPIDS, LIPOPROTEINS AND APOLIPOPROTEINS

OBJECTIVE: To evaluate plasma lipids, lipoproteins and apolipoprotein changes induced by gestational diabetes. STUDY DESIGN: In this case-co ntrol study, 60 women between 26 and 32 weeks of pregnancy were alloca ted to four groups according to lipid status and glucose tolerance: (1 ) normolipemia and no gestational diabetes, (2) normolipemia and gesta tional diabetes, (3) hyperlipemia and no gestational diabetes, and (4) hyperlipemia and gestational diabetes. Total cholesterol, high-densit y lipoprotein cholesterol, low-density lipoprotein cholesterol, very l ow density lipoprotein cholesterol (VLDLc), triglycerides, triglycerid es/very low density lipoprotein (VLDL), apolipoproteins (APO) A(1) ant i APO B, APO B-VLDL and APO B/low-density lipoyrotein were measured. R ESULTS: There were no statistically significant differences in the nor molipemic group of women. Among the hyperlipemic patients, gestational diabetic women showed lower VLDLc when compared to nondiabetic patien ts. CONCLUSION: Our results, comparing groups separated groups by lipi d status, show that the only difference In lipid profile associated wi th glucose intolerance is lower VLDLc in hyperlipemic patients.