WELL-DIFFERENTIATED GASTRIC ADENOCARCINOMA WITH RHABDOID AREAS - A CASE-REPORT WITH IMMUNOHISTOCHEMICAL ANALYSIS

We describe the case of a 73-year-old patient with gastric adenocarcin oma composed of histologically well differentiated glandular areas, ex tensive rhabdoid zones and regions depicting a transition between thes e two constituents. The rhabdoid component showed typical features suc h as abundant eosinophilic cytoplasm, eccentric nuclei, prominent nucl eoli, intense positive immunohistochemical cytoplasmic reaction for vi mentin and less evident immunohistochemical for cytokeratin and epithe lial membrane antigen (EMA). Our findings strongly suggest that the rh abdoid areas probably represent a phenotypic variant of a gastric aden ocarcinoma, otherwise fairly well differentiated, a combination that t o the best of our knowledge has not been previously reported.