MUSCULAR-DYSTROPHIES AND THE DYSTROPHIN-GLYCOPROTEIN COMPLEX

Authors
STRAUB V CAMPBELL KP
Citation
V. Straub et Kp. Campbell, MUSCULAR-DYSTROPHIES AND THE DYSTROPHIN-GLYCOPROTEIN COMPLEX, Current opinion in neurology, 10(2), 1997, pp. 168-175
Citations number
63
Categorie Soggetti
Neurosciences,"Clinical Neurology
Journal title
Current opinion in neurology → ACNP
ISSN journal
13507540
Volume
10
Issue
2
Year of publication
1997
Pages
168 - 175
Database
ISI
SICI code
1350-7540(1997)10:2<168:MATDC>2.0.ZU;2-C
Abstract
Efforts to understand the function of dystrophin, the protein product for the Duchenne muscular dystrophy gene, resulted in the purification of the dystrophin-glycoprotein complex. Over the past year several no vel components of this complex have been identified. Recent studies ha ve extended the number of muscular dystrophies associated with the oli gomeric complex to six genetically distinct diseases, including three new forms of limb-girdle muscular dystrophy and one form of congenital muscular dystrophy.