HEMORHEOLOGICAL CHANGES DURING HUMAN AGING

Citation
Rs. Ajmani et Jm. Rifkind, HEMORHEOLOGICAL CHANGES DURING HUMAN AGING, Gerontology, 44(2), 1998, pp. 111-120
Citations number
82
Categorie Soggetti
Geiatric & Gerontology
Journal title
ISSN journal
0304324X
Volume
44
Issue
2
Year of publication
1998
Pages
111 - 120
Database
ISI
SICI code
0304-324X(1998)44:2<111:HCDHA>2.0.ZU;2-D
Abstract
Various researchers have reported an association of hemorheological, h ematological and metabolic changes with human aging, In this article a n attempt has been made to review the present understanding of hemorhe ological changes and their probable role in the development of certain disorders/diseases during aging, The rise in fibrinogen, blood viscos ity, plasma viscosity, red cell rigidity, fibrin degradation products and early activation of the coagulation system are some of the most pr ominent findings, It is generally agreed that a rise in blood viscosit y factors leads to a state of hypoperfusion which results in impaired microcirculation. The cumulative effect of these changes appears in th e form of a disturbed blood flow profile in older subjects leading to the development or aggravation of various circulatory disorders, Many studies indicate that hemorheological parameters that change in a numb er of diseases prevalent during aging include hypertension, stroke, di abetes. In addition correlations found between hemorheological paramet ers in the aged and decrements in certain cognitive functions and beha vioral patterns suggest that hemorheological changes contribute to non clinical aging changes.