Various researchers have reported an association of hemorheological, h
ematological and metabolic changes with human aging, In this article a
n attempt has been made to review the present understanding of hemorhe
ological changes and their probable role in the development of certain
disorders/diseases during aging, The rise in fibrinogen, blood viscos
ity, plasma viscosity, red cell rigidity, fibrin degradation products
and early activation of the coagulation system are some of the most pr
ominent findings, It is generally agreed that a rise in blood viscosit
y factors leads to a state of hypoperfusion which results in impaired
microcirculation. The cumulative effect of these changes appears in th
e form of a disturbed blood flow profile in older subjects leading to
the development or aggravation of various circulatory disorders, Many
studies indicate that hemorheological parameters that change in a numb
er of diseases prevalent during aging include hypertension, stroke, di
abetes. In addition correlations found between hemorheological paramet
ers in the aged and decrements in certain cognitive functions and beha
vioral patterns suggest that hemorheological changes contribute to non
clinical aging changes.