DECREASED ENERGY DEMANDING PROCESSES IN THE FRONTAL LOBES OF SCHIZOPHRENICS DUE TO NEUROLEPTICS - A P-31-MAGNETO-RESONANCE SPECTROSCOPIC STUDY

Authors
VOLZ HP RZANNY R ROSSGER G HUBNER G KREITSCHMANNANDERMAHR I KAISER WA SAUER H
Citation
Hp. Volz et al., DECREASED ENERGY DEMANDING PROCESSES IN THE FRONTAL LOBES OF SCHIZOPHRENICS DUE TO NEUROLEPTICS - A P-31-MAGNETO-RESONANCE SPECTROSCOPIC STUDY, PSYCHIATRY RESEARCH-NEUROIMAGING, 76(2-3), 1997, pp. 123-129
Citations number
21
Journal title
PSYCHIATRY RESEARCH-NEUROIMAGING → ACNP
ISSN journal
09254927
Volume
76
Issue
2-3
Year of publication
1997
Pages
123 - 129
Database
ISI
SICI code
0925-4927(1997)76:2-3<123:DEDPIT>2.0.ZU;2-C
Abstract
In the present investigation on P-31-magneto-resonance spectroscopic p arameters in the frontal lobe, we found phosphocreatine levels and the ratio phosphocreatine/adenosine triphosphate to be increased (12.62 /- 1.98% resp. 0.31 +/- 0.06) in 50 neuroleptic-treated schizophrenics , whereas no differences were detected in 10 neuroleptic-free patients (11.66 +/- 2.57% resp. 0.29 +/- 0.08) compared to 36 controls (11.37 +/- 1.45 resp. 0.29 +/- 0.04). This result points to a major role of n euroleptics in the metabolism of high-energy phosphates. (C) 1997 Else vier Science Ireland Ltd.