NEUROSTEROIDS ACT ON THE GABA(A) RECEPTOR AT SITES ON THE N-TERMINAL SIDE OF THE MIDDLE OF TM2

Authors
RICK CE YE Q FINN SE HARRISON NL
Citation
Ce. Rick et al., NEUROSTEROIDS ACT ON THE GABA(A) RECEPTOR AT SITES ON THE N-TERMINAL SIDE OF THE MIDDLE OF TM2, NeuroReport, 9(3), 1998, pp. 379-383
Citations number
22
Categorie Soggetti
Neurosciences
Journal title
NeuroReport → ACNP
ISSN journal
09594965
Volume
9
Issue
3
Year of publication
1998
Pages
379 - 383
Database
ISI
SICI code
0959-4965(1998)9:3<379:NAOTGR>2.0.ZU;2-#
Abstract
Two sets of chimeras between alphaxalone-sensitive GABA(A) receptor al pha(2) or beta(1) subunits and the alphaxalone-insensitive glycine rec eptor alpha(1) subunit were constructed to determine the structural do mains important for the modulatory actions of neuroactive steroids. Th ese data suggest that the site of action for neurosteroids on GABA(A) receptors is not the same as that for volatile anesthetics and ethanol , but is on the N-terminal side of the middle of TM2. (C) 1998 Rapid S cience Ltd.