IMMOBILIZED VANCOMYCIN AS CHIRAL STATIONARY-PHASE IN PACKED CAPILLARYLIQUID-CHROMATOGRAPHY

Authors
SVENSSON LA KARLSSON KE KARLSSON A VESSMAN J
Citation
La. Svensson et al., IMMOBILIZED VANCOMYCIN AS CHIRAL STATIONARY-PHASE IN PACKED CAPILLARYLIQUID-CHROMATOGRAPHY, Chirality, 10(3), 1998, pp. 273-280
Citations number
40
Categorie Soggetti
Chemistry Medicinal","Chemistry Analytical","Chemistry Inorganic & Nuclear
Journal title
Chirality → ACNP
ISSN journal
08990042
Volume
10
Issue
3
Year of publication
1998
Pages
273 - 280
Database
ISI
SICI code
0899-0042(1998)10:3<273:IVACSI>2.0.ZU;2-T
Abstract
Fused silica-packed capillary columns containing vancomycin immobilize d by reductive amination on an aldehyde-silica were used to separate e nantiomers of some non-steroidal anti-inflammatory drugs. Attempts hav e been made to qualitatively explain the influence of various mobile p hase compositions on the enantioselective retention. The effects of mo bile phase pH, buffer, and organic modifier concentrations were invest igated as well as the influence of salts of hydrophobic ions added to the mobile phase to induce ion pair retention. (C) 1998 Wiley-Liss, In c.