ENHANCEMENT OF CYTOTOXIC ACTIVITY OF ASCORBATE BY ACER NIKOENSE MAXIM. EXTRACTS

Authors
SAKAGAMI H ANZAI S GOTO S TAKEDA M
Citation
H. Sakagami et al., ENHANCEMENT OF CYTOTOXIC ACTIVITY OF ASCORBATE BY ACER NIKOENSE MAXIM. EXTRACTS, Anticancer research, 17(6D), 1997, pp. 4453-4456
Citations number
14
Categorie Soggetti
Oncology
Journal title
Anticancer research → ACNP
ISSN journal
02507005
Volume
17
Issue
6D
Year of publication
1997
Pages
4453 - 4456
Database
ISI
SICI code
0250-7005(1997)17:6D<4453:EOCAOA>2.0.ZU;2-U
Abstract
Millimolar concentrations of ascorbic acid or sodium ascorbate induced cytotoxicity against human glioblastoma T98G cells. Addition of hot w ater and sodium hydroxide extracts of the bark of Acer nikoense Maxim. synergistically enhanced the cytotoxic activity of ascorbate. Human p eripheral blood lymphocytes and polymorphonuclear cells were relativel y resistant to ascorbate, the Acer nikoense Maxim. extract, or a combi nation of them. The extracts stimulated the degradation of ascorbates via ascorbyl radical production, in parallel with their ability to sti mulate the cytotoxic activity of ascorbate. The results suggest the me dicinal efficacy of the Acer nikoense Maxim. extracts.