GROUPING OF ANTICANCER DRUGS BASED ON ADMINISTRATION METHOD RELATED TOXICITY PATTERNS IN RATS

As part of the study of the appropriate usage of anticancer drugs, and the effects of the administration method (single dose, or divided dos es) on the death rate from toxicity, five anticancer drugs (nimustine hydrochloride=ACNU, cyclophosphamide=CY, carboplatine = CBDCA, mitomyc in C=MMC, vindesine=VDS) were studied in F-344 rats. A resuced death r ate from toxicity was achieved by divided-dose administration of ACNU and CBDCA (group 1), but it was higher for CY and VDS (group 2), and t here was no significant difference with MMC (group 3). In conclusion, the drugs were divided into three groups according to the administrati on method-related toxicity patterns. Improved knowledge of the propert ies of anticancer drugs is important for the success of chemotherapy.