Y. Mizushima et al., GROUPING OF ANTICANCER DRUGS BASED ON ADMINISTRATION METHOD RELATED TOXICITY PATTERNS IN RATS, Anticancer research, 17(6D), 1997, pp. 4611-4614
As part of the study of the appropriate usage of anticancer drugs, and
the effects of the administration method (single dose, or divided dos
es) on the death rate from toxicity, five anticancer drugs (nimustine
hydrochloride=ACNU, cyclophosphamide=CY, carboplatine = CBDCA, mitomyc
in C=MMC, vindesine=VDS) were studied in F-344 rats. A resuced death r
ate from toxicity was achieved by divided-dose administration of ACNU
and CBDCA (group 1), but it was higher for CY and VDS (group 2), and t
here was no significant difference with MMC (group 3). In conclusion,
the drugs were divided into three groups according to the administrati
on method-related toxicity patterns. Improved knowledge of the propert
ies of anticancer drugs is important for the success of chemotherapy.