DIRECT CONVERSION OF PYRANOSE ANOMERIC OH-]F-]R IN THE ARTEMISININ FAMILY OF ANTIMALARIAL TRIOXANES

Authors
WOO SH PARKER MH PLOYPRADITH P NORTHROP J POSNER GH
Citation
Sh. Woo et al., DIRECT CONVERSION OF PYRANOSE ANOMERIC OH-]F-]R IN THE ARTEMISININ FAMILY OF ANTIMALARIAL TRIOXANES, Tetrahedron letters, 39(12), 1998, pp. 1533-1536
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
12
Year of publication
1998
Pages
1533 - 1536
Database
ISI
SICI code
0040-4039(1998)39:12<1533:DCOPAO>2.0.ZU;2-Q
Abstract
Eleven examples form the basis of a short and effective synthetic meth od for replacement of an anomeric fluorine atom by saturated, unsatura ted, aryl and heteroaryl carbon nucleophiles to prepare alpha- or beta -oriented C-10-R derivatives of the trioxane 10-deoxoartemisinin. (C) 1998 Elsevier Science Ltd. All rights reserved.