SYNTHESIS OF ISOTOPICALLY LABELED CARDIOLIPINS

A phosphotriester approach is used to access the complex phospholipid, cardiolipin (1) with polyunsaturated fatty acid chains. The synthetic method allows the specific incorporation of isotopic labels within th e molecule and sets up the desired configuration at all three chiral c entres which corresponds to the configuration of the natural phospholi pid. Using such a methodology a range of pure optically active cardiol ipin molecular species have been synthesized. (C) 1998 Elsevier Scienc e Ltd. All rights reserved.