MECHANISMS OF TRANSCRIPTIONAL ACTIVATION - DIFFERENCES AND SIMILARITIES BETWEEN YEAST, DROSOPHILA, AND MAN

Activation of transcription requires an interplay between enhancer-bin ding factors and components of the general transcription machinery, Ne w developments within the past few years suggest that novel cofactors are required for relaying specific activation signals to the RNA polym erase II transcription complex in order to achieve enhanced levels of mRNA synthesis. The role of these different cofactors in mediating act ivation and potential differences in their utilization by divergent or ganisms, however, raise new questions about the mechanisms of transcri ptional regulation.