CHROMATIN REMODELING AND TRANSCRIPTION

Authors
TSUKIYAMA T WU C
Citation
T. Tsukiyama et C. Wu, CHROMATIN REMODELING AND TRANSCRIPTION, Current opinion in genetics & development, 7(2), 1997, pp. 182-191
Citations number
140
Categorie Soggetti
Biology,"Cell Biology","Biothechnology & Applied Migrobiology","Genetics & Heredity
Journal title
Current opinion in genetics & development → ACNP
ISSN journal
0959437X
Volume
7
Issue
2
Year of publication
1997
Pages
182 - 191
Database
ISI
SICI code
0959-437X(1997)7:2<182:CRAT>2.0.ZU;2-D
Abstract
Recent advances highlight two important chromatin remodeling systems i nvolved in the transcriptional process. One system includes several me mbers of the evolutionarily conserved SWI2/SNF2 family found in distin ct multiprotein complexes with ATP-dependent nucleosome destabilizing activity; the other is the enzymatic system that governs histone acety lation and deacetylation. Identification of the catalytic subunits of these opposing histone-modifying activities reveal conserved proteins defined genetically as transcriptional regulators.