DECONSTRUCTING THE NUCLEUS - GLOBAL ARCHITECTURE FROM LOCAL INTERACTIONS

Authors
MARSHALL WF FUNG JC SEDAT JW
Citation
Wf. Marshall et al., DECONSTRUCTING THE NUCLEUS - GLOBAL ARCHITECTURE FROM LOCAL INTERACTIONS, Current opinion in genetics & development, 7(2), 1997, pp. 259-263
Citations number
46
Categorie Soggetti
Biology,"Cell Biology","Biothechnology & Applied Migrobiology","Genetics & Heredity
Journal title
Current opinion in genetics & development → ACNP
ISSN journal
0959437X
Volume
7
Issue
2
Year of publication
1997
Pages
259 - 263
Database
ISI
SICI code
0959-437X(1997)7:2<259:DTN-GA>2.0.ZU;2-1
Abstract
Recent advances in fluorescence in situ hybridization and three-dimens ional microscopy have revealed a high degree of large-scale order in t he nucleus, indicating that the position of each gene within the nucle us is not random. As with any other biological phenomenon, this large- scale organization must ultimately be specified by molecular interacti ons. Biochemical and molecular investigations have revealed a small se t of local molecular-scale interactions that can be used together in a combinatorial fashion to establish a global large-scale nuclear archi tecture.