NATURAL LIGAND OF MOUSE CD1D1 - CELLULAR GLYCOSYLPHOSPHATIDYLINOSITOL

Citation
S. Joyce et al., NATURAL LIGAND OF MOUSE CD1D1 - CELLULAR GLYCOSYLPHOSPHATIDYLINOSITOL, Science, 279(5356), 1998, pp. 1541-1544
Citations number
27
Categorie Soggetti
Multidisciplinary Sciences
Journal title
ISSN journal
00368075
Volume
279
Issue
5356
Year of publication
1998
Pages
1541 - 1544
Database
ISI
SICI code
0036-8075(1998)279:5356<1541:NLOMC->2.0.ZU;2-V
Abstract
Mouse CD1d1, a member of the CD1 family of evolutionarily conserved ma jor histocompatibility antigen-like molecules, controls the differenti ation and function of a T lymphocyte subset, NK1(+) natural T cells, p roposed to regulate immune responses. The CD1d1 crystal structure reve aled a large hydrophobic binding site occupied by a ligand of unknown chemical nature. Mass spectrometry and metabolic radiolabeling were us ed to identify cellular glycosylphosphatidylinositol as a major natura l ligand of CD1d1. CD1d1 bound glycosylphosphatidylinositol through it s phosphatidylinositol aspect with high affinity. Glycosylphosphatidyl inositol or another glycolipid could be a candidate natural ligand for CD1d1-restricted T cells.