TOOLS FOR VISUALIZATION AND INTEGRATION OF INTERMEDIATE SEQUENCING RESULTS IN LARGE DISEASE GENE DISCOVERY PROJECTS

We describe two Java applets which are useful for insightful presentat ion of intermediate experimental data in gene discovery projects invol ving large scale sequencing. One of these applets provides a physical map of a genomic region and provides easy access to the second applet, which furnishes a detailed map of sequence contigs associated with cl ones on the physical map. In particular, the second applet displays al l the known information about each contig, including the presence of e xons, database homology 'hits', repetitive elements and other features ; the graphics are linked to other World Wide Web pages, providing det ailed information on each feature. These applets should be useful to o ther research groups working on large sequencing projects. (C) 1998 El sevier Science B.V.