SERTRALINE DOES NOT INHIBIT CYTOCHROME-P450 3A-MEDIATED DRUG-METABOLISM IN-VIVO

Authors
PRESKORN SH ALDERMAN J GREENBLATT DJ HORST WD
Citation
Sh. Preskorn et al., SERTRALINE DOES NOT INHIBIT CYTOCHROME-P450 3A-MEDIATED DRUG-METABOLISM IN-VIVO, Psychopharmacology bulletin, 33(4), 1997, pp. 659-665
Citations number
12
Journal title
Psychopharmacology bulletin → ACNP
ISSN journal
00485764
Volume
33
Issue
4
Year of publication
1997
Pages
659 - 665
Database
ISI
SICI code
0048-5764(1997)33:4<659:SDNIC3>2.0.ZU;2-K
Abstract
The in vivo effect of sertraline on oxidative drug metabolism mediated by cytochrome P450 (CYP) 3A was assessed by coadministration with alp razolam, carbamazepine, and terfenadine in three separate studies. Ser traline at doses of 50 to 200 mg/day for 10 to 20 days did not alter t he pharmacokinetics of these CYP3A substrates/drugs.