LINEAR IGA DISEASE AND ULCERATIVE-COLITIS

Linear IgA disease is an acquired bullous disease of the skin characte rized by linear IEA deposits along the dermal-epidermal junction. Infl ammatory bowel diseases have been rarely reported in association with linear IgA disease. We have recently observed a patient suffering from ulcerative colitis who developed a cutaneous bullous eruption that wa s diagnosed as a linear IgA disease. Foreign antigens penetrating the inflamed bowel mucosa might give rise to the production of autoantibod ies cross-reacting with the cutaneous antigens involved in the pathoge nesis of linear IgA disease.