MAXIMUM ANDROGEN BLOCKADE USING LHRH AGONIST BUSERELIN IN COMBINATIONWITH SHORT-TERM (2 WEEKS) OR LONG-TERM (CONTINUOUS) CYPROTERONE-ACETATE IS NOT SUPERIOR TO STANDARD ANDROGEN DEPRIVATION IN THE TREATMENT OF ADVANCED PROSTATE-CANCER - FINAL ANALYSIS OF EORTC GU GROUP TRIAL-30843

This is the final analysis of EORTC GU Group Trial 30843 in which the treatment of advanced, metastatic prostate cancer with a combination o f the LHRH agonist buserelin (nasal spray) and cyproterone acetate (An drocur), either continuously of only during the first 2 weeks, was com pared with orchidectomy, There was no significant difference between t he three arms as far as response rate, time to progression (subjective and objective) and duration of survival are concerned, Retrospective stratification according to the most important prognostic factors did not change the conclusions, Possible reasons for the difference with t rial 30853, which used the same entry criteria but compared goserelin and flutamide with orchidectomy, are discussed, Reasons for using cypr oterone acetate in combination treatment are the prevention of flare o f the disease after LHRH agonists only and the prevention/reduction of toxicity in the form of hot flushes.