in recent years the application of 3D video endoscopic systems in clin
ical routine, especially, in the field of endoscopic surgery, has incr
eased steadily. The number of 3D video endoscopic systems used in the
operating theatre today is obviously lower-than the number of establis
hed traditional 2D video endoscopic systems, The hesitant application
of the new technology can be mainly explained try the lack of evaluati
on of its influence on the surgical procedure and on patient benefit a
s well as by the need for specific economic analysis, The. starting po
int for our investigations was to analyze the influence of 3D video en
doscopy on endoscopically guided manipulations in general, in order to
achieve quantitative statements we performed laboratory experiments u
sing human factors analyzing methods, In the next step we performed cl
inical field studies of the application of 3D video endoscopic systems
for a side-by-side comparison of 2D and 3D systems, These studies sho
wed that the use of 3D video endoscopy has an improving influence on e
ndoscopically guided surgical manipulations is well as on the intraope
rative procedures, We also found that spatial visual perception of ste
reoscopic images of 3D video systems may cause problems for some users
, For the validation of stereoscopic visualization systems we addition
ally studied the influence of isolated technical, optical, and physiol
ogical parameters on visual perception as well as on transposition int
o visually guided manipulations. Detailed results of these investigati
ons concerning the influence of 3D video endoscopy on binocular percep
tion are presented.