THE CYCLIN FAMILY OF BUDDING YEAST - ABUNDANT USE OF A GOOD IDEA

Cyclins are highly conserved proteins that activate cyclin-dependent k inases (CDKs) to regulate the cell cycle, transcription and other cell ular processes. The completion of tbe genome sequence of tbe budding y east Saccharomyces cerevisiae allows an appraisal of the functions of the entire complement of cyclins in a eukaryotic organism. The cyclin family of budding yeast is reviewed from a functional perspective with an emphasis on what genetic and biochemical experiments have revealed about cyclin-CDK substrates.