A clone encoding ovine preprogastrin was isolated from a sheep genomic
library. The deduced 104 amino acid sequence of ovine preprogastrin w
as 92% and 68% identical to the sequences of bovine and human preproga
strin, respectively. While the similarity was greatest in the gastrin-
17 sequence, an unexpected similarity was also observed in the N-termi
nus of mature progastrin.