FEASIBILITY, TOXICITY, AND BIOLOGIC RESPONSE OF INTERLEUKIN-2 AFTER CONSOLIDATION CHEMOTHERAPY FOR ACUTE MYELOGENOUS LEUKEMIA - A REPORT FROM THE CHILDRENS CANCER GROUP
El. Sievers et al., FEASIBILITY, TOXICITY, AND BIOLOGIC RESPONSE OF INTERLEUKIN-2 AFTER CONSOLIDATION CHEMOTHERAPY FOR ACUTE MYELOGENOUS LEUKEMIA - A REPORT FROM THE CHILDRENS CANCER GROUP, Journal of clinical oncology, 16(3), 1998, pp. 914-919
Purpose: Although remission can be achieved in 80% of children with ac
ute myelogenous leukemia (AML), many patients experience relapse. Beca
use interleukin-2 (IL-2) can induce remission in patients with overt e
vidence of AML, we hypothesized that IL-2 given to patients in first r
emission alter intensive consolidation chemotherapy might prevent rela
pse. This study sought to determine whether such an approach was feasi
ble. Patients and Methods: Twenty-one patients in complete remission r
eceived IL-2 after completion of treatment on Children's Cancer Group
(CCG) protocol 2941. Recombinant IL-2 9 x 10(6) IU/m(2) daily by conti
nuous intravenous infusion (CIV) was given for 4 days. After 4 days re
st, IL-2 1.6 x 10(6) IU/m(2) daily CIV was resumed for 10 days. We mon
itored patients for toxicity and measured absolute lymphocyte count th
e absolute count of cells that express CD56 and CD3 antigen, and solub
le IL-2 receptor alpha-chain (sIL-2R alpha) levels before the start of
IL-2 and after completion of each of the two courses of IL-2. Results
: Observed toxicities included fever (57%), vascular leak (48%), hypot
ension (38%), tachycardia (14%), rash (29%), septicemia (5%), thromboc
ytopenia (29%), elevated transaminase (14%), electrolyte disturbance (
29%), and hyperglycemia (10%). No patient required cardiac pressors or
transfer to an intensive care unit. All patients studied developed an
increase in lymphocyte count, CD56 count, CD3 count, and sIL-2R alpha
levels after treatment with IL-2. Conclusion: This schedule of IL-2 w
as reasonably well tolerated by children with AML in first remission.
After treatment increased levels of sIL-2R alpha were observed, CCG is
conducting a randomized prospective trial to assess the efficacy of I
L-2 to prevent the relapse of AML (CCG-2961). (C) 1998 by American Soc
iety of Clinical Oncology.