ESTROGEN AND PROGESTIN INHIBIT INVASIVENESS OF GYNECOLOGIC METASTATICCANCER-CELLS TO BLOOD-VESSEL ENDOTHELIUM

The Boyden chamber method showed that the invasiveness to reconstitute d blood vessel endothelium of metastatic gynecologic cancer cell lines of the uterine cervix (MS751 and ME-180), endometrium (AN3 CA), and o vary (SK-OV-3 and PA-1) was significantly higher than of primary cance r cell lines of the cervix (HeLa and C-33 A), endometrium (Ishikawa, H EC-1-A and HHUA), and ovary (MCAS and Caov-3), and that the invasivene ss was inhibited by estradiol or progestin in the metastatic cells but not in the primary cells. These results suggest that metastatic cance r cells by themselves increase the potential of blood vessel invasion, which can be inhibited by estrogen and progestin administration.