THE VALUE OF THE PROGNOSTIC FACTORS IN OVARIAN GRANULOSA-CELL TUMORS

The malignant potential of granulosa cell tumors (GCT) of the ovary is much debated. This study includes 18 patients with a diagnosis of GCT of the ovary. Clinical and pathologic data from patients were compare d with flow cytometry ploidy, Ki-67 reactivity and p53 overexpression in order to determine their prognostic usefulness. There was no correl ation between ploidy and stages or between ploidy and biological behav ior. On the other hand, mitotic count, Ki-67 reactivity and p53 overex pression were associated with stages of disease, recurrent onset and s urvival. We believe that ploidy, Ki-67 and p53 should be considered im portant prognostic factors for GCT in association with the other more studied prognostic factors, even if no conclusions can be reached.